Evaluation of the correlation between trigeminal nerve atrophy and trigeminal neuralgia using multimodal image fusion: A single-center retrospective study

• Published in: Clinical neurology and neurosurgery Vol. 243; p. 108387
• Main Authors: Li, Yang, Cao, Boyang, Wang, Yinzhan, Shi, Hailiang, Du, Yihui, Shi, Haowei, Zhang, Kuo, Qian, Tao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2024; Elsevier Limited
• Subjects: 3D-FIESTA; 3D-slicer; 3D-TOF-MRA; Adult; Aged; Atrophy; Atrophy - pathology; Balloon treatment; Decompression; Diagnosis; Female; Females; Hospitals; Humans; Image processing; Imaging, Three-Dimensional - methods; Male; Microvascular Decompression Surgery - methods; Microvasculature; Middle Aged; Multimodal Imaging - methods; Neuralgia; Normal distribution; Offending vessel; Pain; Patients; Primary trigeminal neuralgia atrophy; Retrospective Studies; Software; Surgery; Trigeminal ganglion; Trigeminal nerve; Trigeminal Nerve - diagnostic imaging; Trigeminal Nerve - pathology; Trigeminal Nerve - surgery; Trigeminal Neuralgia - diagnostic imaging; Trigeminal Neuralgia - surgery; 3D-TOF-MRA; Primary trigeminal neuralgia atrophy; 3D-FIESTA; Offending vessel; 3D-slicer
• ISSN: 0303-8467; 1872-6968; 1872-6968
• DOI: 10.1016/j.clineuro.2024.108387

3D-Slicer is an open-source medical image processing and visualization software. In the surgical treatment of trigeminal neuralgia, it is commonly used to predict the responsible vessels. However, there are few reports on the use of 3D-Slicer software to quantitatively measure the bilateral trigeminal nerve volume in patients with primary trigeminal neuralgia (PTN) based on the three-dimensional images. Therefore, this study aims to explore the role of three-dimensional fused images processed by 3D-Slicer in the evaluation of trigeminal nerve atrophy, providing an objective basis for the diagnosis of PTN. 57 PTN patients who underwent microvascular decompression (MVD) or percutaneous balloon compression (PBC) surgery in Hebei general hospital between January 2020 and April 2023 were included. Additionally, 30 patients with facial spasms(HFS) were included as a control group. All patients underwent 3D-TOF-MRA and 3D-FIESTA sequence examinations. Comparisons of bilateral trigeminal nerve volumes within and between groups were conducted by performing image fusion using 3D-slicer. The volume of the affected trigeminal nerve in the MVD group (33.96 mm³±12.61 mm³) and PBC group (23.05 mm³±7.71 mm³) was smaller than that of the unaffected trigeminal nerve in the MVD group (39.61 mm³±12.83 mm³) and PBC group (26.14 mm³±6.42 mm³), as well as the average volume of the trigeminal nerve in the control group (40.27 mm³±10.25 mm³) (P<0.05). The differences in bilateral trigeminal ganglion volume (∆V) was significant between the MVD group (∆V=23.59 %±14.32 %) and the control group (∆V=14.64 %±10.00 %) (P<0.05). There was no statistical difference in the trigeminal nerve volume difference between the MVD group (∆V=23.59 %±14.32 %) and the PBC group (∆V=26.52 %±15.00 %) (P>0.05). Trigeminal nerve atrophy is correlated with primary trigeminal neuralgia. 3D-slicer software can quantitatively measure trigeminal nerve volume and assist in the diagnosis of primary trigeminal neuralgia based on the difference in bilateral trigeminal nerve volumes. However, trigeminal nerve atrophy is not associated with postoperative pain recurrence in patients. •Trigeminal nerve atrophy strongly links to PTN, possibly as a marker for PTN.•Using multimodal image fusion improved the accuracy of nerve volume measurements.•Providing new insights for standardized measurement of nerve volume.•The 3D-Slicer is also highly applicable to primary healthcare institutions.