Convergent synthesis of proteins using peptide-aminothiazoline

Sequential peptide coupling plays a central role in chemical protein synthesis. This paper describes a new peptide derivative, peptide-aminothiazoline (At), whereof the C-terminus is functionalized with 2-aminothiazoline. Peptide-At streamlined the sequential peptide ligation in a one-pot manner and...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 59; no. 9; pp. 1351 - 13513
Main Authors Okamoto, Ryo, Shibata, Hiroyuki, Yatsuzuka, Takahiro, Hanao, Takuya, Maki, Yuta, Kabayama, Kazuya, Miura, Ayane, Fukase, Koichi, Kajihara, Yasuhiro
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 09.11.2023
Royal Society of Chemistry
Subjects
Chemical synthesis
Chemistry
Chemistry, Multidisciplinary
Convergence
Glycoproteins
Physical Sciences
Protein synthesis
Proteins
Science & Technology
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Summary:Sequential peptide coupling plays a central role in chemical protein synthesis. This paper describes a new peptide derivative, peptide-aminothiazoline (At), whereof the C-terminus is functionalized with 2-aminothiazoline. Peptide-At streamlined the sequential peptide ligation in a one-pot manner and demonstrated the convergent synthesis of a circular protein and homogeneous glycoproteins. Peptide-aminothiazoline enabled the sequential peptide ligation in one-pot manner and demonstrated convergent synthesis of a circular protein and homogeneous glycoproteins.
Bibliography:https://doi.org/10.1039/d3cc04387h
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc04387h