The effects of 4-aminopyridine on cognitive function in patients with multiple sclerosis: a pilot study

4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performa...

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Bibliographic Details
Published inNeurology Vol. 44; no. 9; p. 1701
Main Authors Smits, R C, Emmen, H H, Bertelsmann, F W, Kulig, B M, van Loenen, A C, Polman, C H
Format Journal Article
LanguageEnglish
Published United States 01.09.1994
Subjects
4-Aminopyridine - therapeutic use
Adult
Aged
Cognition Disorders - drug therapy
Cognition Disorders - etiology
Double-Blind Method
Female
Humans
Male
Middle Aged
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Neuropsychological Tests
Pilot Projects
Placebos
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Summary:4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo-controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
ISSN:0028-3878
1526-632X
DOI:10.1212/WNL.44.9.1701