CYCLOPROPANATION OF CARBON-CARBON DOUBLE BONDS IN RING D OF ERGOT ALKALOIDS

Some ergot alkaloid derivatives containing a double bond in ring D have been reacted with diazomethane/palladium diacetate reagent to result in formation of a fused cyclopropane ring. This procedure proved to be generally applicable for cyclopropanation of Ergot alkaloids.

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Bibliographic Details
Published inHeterocycles Vol. 87; no. 7; pp. 1553 - 1560
Main Authors Incze, Maria, Doernyei, Gabor, Kovacs, Peter, Egyed, Orsolya, Hayos, Gyorgy, Szantay, Csaba
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2013
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Cyclopropanation
Carbene
Ergot Alkaloid
(+)-LYSERGIC ACID
DERIVATIVES
MM2 Calculation
Diazomethane
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Summary:Some ergot alkaloid derivatives containing a double bond in ring D have been reacted with diazomethane/palladium diacetate reagent to result in formation of a fused cyclopropane ring. This procedure proved to be generally applicable for cyclopropanation of Ergot alkaloids.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-13-12735