BISINDOLE ALKALOIDS CONDENSED WITH A CYCLOPROPANE RING, PART 1. 14,15-CYCLOPROPANOVINBLASTINE AND - VINCRISTINE

A new type of vinblastine and vincristine derivatives was synthesized. The carbon carbon double bond in position 14 and 15 of the vindoline ring was cyclopropanated. In the course of the synthetic work 14,15-cyclopropano-vindoline was coupled with catharanthine, resulting in the cyclopropanated anhy...

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Bibliographic Details
Published inHeterocycles Vol. 89; no. 3; pp. 653 - 668
Main Authors Keglevich, Peter, Hazai, Laszlo, Dubrovay, Zsofia, Dekany, Miklos, Szantay, Csaba, Kalaus, Gyoergy
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
FEASIBILITY
CATHARANTHUS-ROSEUS
VINDOLINE
NATURAL-PRODUCTS
VINBLASTINE
DERIVATIVES
LINES
DON,G. CELL-CULTURES
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Summary:A new type of vinblastine and vincristine derivatives was synthesized. The carbon carbon double bond in position 14 and 15 of the vindoline ring was cyclopropanated. In the course of the synthetic work 14,15-cyclopropano-vindoline was coupled with catharanthine, resulting in the cyclopropanated anhydrovinblastine as a key intermediate to 14,15-cyclopropano-vinblastine and vincristine.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-13-12918