Clinical use of digitalis glycosides

The pharmacology of digitalis compounds is reviewed, and the clinical use of the cardiac glycosides is discussed with particular attention to the selection of patients for digitalis therapy and to a study of the usefulness of various methods to monitor digitalis therapy. The discussion includes phar...

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Bibliographic Details
Published inAmerican journal of hospital pharmacy Vol. 33; no. 2; p. 179
Main Author Huffman, D H
Format Journal Article
LanguageEnglish
Published United States 01.02.1976
Subjects
Digitalis Glycosides - adverse effects
Digitalis Glycosides - metabolism
Digitalis Glycosides - pharmacology
Digitalis Glycosides - therapeutic use
Humans
Kinetics
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Summary:The pharmacology of digitalis compounds is reviewed, and the clinical use of the cardiac glycosides is discussed with particular attention to the selection of patients for digitalis therapy and to a study of the usefulness of various methods to monitor digitalis therapy. The discussion includes pharmacokinetics, clinical considerations, and digitalis toxicity and its treatment. It is concluded that the digitalis glycosides remain the most useful and reliable drugs for producing a long-term increase in myocardial contractility. However, in view of the high frequency of toxicity, it is important to consider the possibility that these drugs may have been overused.
ISSN:0002-9289
DOI:10.1093/ajhp/33.2.179