Blood levodopa levels and unified Parkinson's disease rating scale function: with and without exercise

We studied 10 regular exercising men with Parkinson's disease on levodopa (LD) under two conditions--no exercise and vigorous exercise started 1 hour after LD ingestion. We compared LD levels and motor scores on the Unified Parkinson's Disease Rating Scale (UPDRS). There was a high degree...

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Bibliographic Details
Published inNeurology Vol. 43; no. 5; p. 1040
Main Authors Goetz, C G, Thelen, J A, MacLeod, C M, Carvey, P M, Bartley, E A, Stebbins, G T
Format Journal Article
LanguageEnglish
Published United States 01.05.1993
Subjects
Aged
Exercise
Humans
Levodopa - blood
Levodopa - therapeutic use
Male
Middle Aged
Parkinson Disease - blood
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Physical Exertion
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Summary:We studied 10 regular exercising men with Parkinson's disease on levodopa (LD) under two conditions--no exercise and vigorous exercise started 1 hour after LD ingestion. We compared LD levels and motor scores on the Unified Parkinson's Disease Rating Scale (UPDRS). There was a high degree of agreement between plasma LD level and the patients' UPDRS scores 30 minutes later (mean Eta2 = 0.84) in both conditions, with no difference between the two. We conclude that LD levels accurately reflect UPDRS motor function in these patients, and that vigorous exercise started 1 hour after LD ingestion does not influence LD or motor scores.
ISSN:0028-3878
DOI:10.1212/WNL.43.5.1040