A GREEN AND HIGHLY EFFICIENT SYNTHESIS OF 5,5-(PHENYLMETHYLENE)BIS(1,3-DIOXANE-4,6-DIONE) DERIVATIVES IN BIOBASED GLUCONIC ACID AQUEOUS SOLUTION

A green and highly efficient synthesis of 5,5-(phenylmethylene)bis(1,3-dioxane-4,6-dione) derivatives through tandem Knoevenagel condensation and Michael addition of aromatic aldehydes and 1,3-dioxane-4,6-dione in gluconic acid aqueous solution (GAAS) is described. Gluconic acid aqueous solution cou...

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Bibliographic Details
Published inHeterocycles Vol. 94; no. 6; pp. 1115 - 1122
Main Authors Xu, Zhaohui, Zhou, Peng, Tu, Yuanhong, Liu, Deyong, Liao, Weilin, Liao, Chuanwen
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2017
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Aromatic Aldehyde
ISOPROPYLIDENE MALONATE
POT
1,3-Dioxane-4,6-dione
CONDENSATION
5,5-(Phenylmethylene)bis(1,3-dioxane-4,6-dione) Derivative
Gluconic Acid Aqueous Solution
SOLVENT
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Summary:A green and highly efficient synthesis of 5,5-(phenylmethylene)bis(1,3-dioxane-4,6-dione) derivatives through tandem Knoevenagel condensation and Michael addition of aromatic aldehydes and 1,3-dioxane-4,6-dione in gluconic acid aqueous solution (GAAS) is described. Gluconic acid aqueous solution could be recycled and reused several times without significant loss of its effciency.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-17-13673