Clinical Course of SARS CoV-2 Infection in Hospitalized Pregnant Patients

• Published in: Pakistan Armed Forces medical journal Vol. 72; no. 6; pp. 1858 - 62
• Main Authors: Ansari, Asma, Siraj, Asifa, Khan, Sumaira, Jalil, Rabiya, Choudary, Abeera, Khalil, Hafsa
• Format: Journal Article
• Language: English
• Published: Rawalpindi Knowledge Bylanes 31.12.2022; AsiaNet Pakistan (Pvt) Ltd; Army Medical College Rawalpindi
• Subjects: Anemia; Asthma; Cesarean section; Childbirth & labor; Clinical course; Comorbidity; Coronaviruses; COVID-19; Disease transmission; Fever; Gallbladder diseases; Hospitalization; Hospitals; Hypertension; Hypothyroidism; Infections; Intensive care; Laboratories; Mortality; Neonatal; Obstetrics; Patients; Pregnancy; Pregnant women; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Vital signs; Womens health; China; United States > US
• ISSN: 0030-9648; 2411-8842
• DOI: 10.51253/pafmj.v72i6.4512

Objective: To determine the clinical course and outcome of hospitalized pregnant patients with laboratory confirmed SARS CoV-2 (COVID-19) infection Study Design: Prospective longitudinal study Place and Duration of Study: Obstetrics Units of Pak Emirates Military Hospital and Combined Military Hospital, Rawalpindi Pakistan, from May to Jun 2020. Methodology: All patients reporting for childbirth were tested for SARS-CoV-2, and those testing positive were included. The primary outcome was virus clearance time and categorization according to the severity of the disease into asymptomatic,mild, moderate, severe and critical. Furthermore, a comparison was made between the presence of comorbid conditions and symptoms in the category of COVID-19. In addition, neonatal sample evaluation for SARS-CoV-2 was done. Results: Out of the 881 women giving birth, 41(4.6%) tested positive for SARS Cov-2. Majority were asymptomatic 28(68.3%)followed by mild 8(19.5%), moderate 4(9.8%) and severe 1(2.4%) category. There was a significant association of the COVID categories with symptoms (p-value<0.005) and comorbid condition (p-value<0.001). The mean virus clearance time was 8.20±1.66 days. During hospital stay 34(82.9%) delivered. All 34(100%) delivered babies had no evidence of vertical transmission. Conclusion: Pregnant women with COVID-19 infection have a nearly similar clinical course to non-COVID women in this study. There is also no evidence of vertical transmission to the neonate.