Comparison among the Atherogenic Index of Plasma, Ratios of Lipoproteins, Apolipoproteins and Cholesterol Retention Factor (CRF) inPatients with Metabolic Syndrome

• Published in: Pakistan Armed Forces medical journal Vol. 73; no. 3; pp. 637 - 41
• Main Authors: Khan, Sikandar Hayat, Afzal, Ahmed Hayat, Gilani, Mehreen, Akhtar, Faisal Naveed, Shahid, Rahat
• Format: Journal Article
• Language: English
• Published: Rawalpindi Knowledge Bylanes 30.06.2023; AsiaNet Pakistan (Pvt) Ltd; Army Medical College Rawalpindi
• Subjects: Analysis; Apo-B/Apo-A1; Apolipoproteins; Atherogenic index of plasma (AIP); Blood lipids; Body mass index; Cholesterol; Cholesterol retention factor (CRF); Ethylenediaminetetraacetic acid; Fatty acids; Gender; HDLc/LDLc; High density lipoprotein; HOMA-IR; Homeostasis; Hospital patients; Insulin resistance; Lipids; Lipoproteins; Metabolic syndrome; Plasma; Ratios; Resveratrol; Retention; Triglycerides
• ISSN: 0030-9648; 2411-8842
• DOI: 10.51253/pafmj.v73i3.6280

Objective: To evaluate various lipid, lipoprotein and apolipoprotein ratios among participants with and without metabolic syndrome. Study Design: Comparative cross-sectional study. Place and Duration of Study: Naval Hospital, Islamabad Pakistan, from Jan 2019 to Dec 2020. Methodology: We selected 164 patients with metabolic syndrome. Metabolic syndrome was diagnosed as per “NCEP-defined metabolic syndrome criteria”. Insulin resistance was calculated using Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Various apolipoproteins were calculated using the turbidimetric method on Humastar-200 and lipoproteins by direct detergent methods. Results: The differences for Apo-B/Apo-A1 were found to be higher among metabolic syndrome subjects [{Metabolic syndrome (n=83):0.55±0.22} vs {Non-Metabolic syndrome (n=81):0.50±0.29}, p=0.271]. Area Under Curve (AUC) was highest for the atherogenic index of plasma [0.744], followed by both total cholesterol/HDLc [0.641], Cholesterol Retention Factor (CRF) having [0.641], Apo-B/Apo-A1[0.593] and HDLc/LDLc [0.418]. Conclusion: Differences between subjects with and without NCEP-defined metabolic syndrome were significant for the atherogenic index of plasma (AIP), HDLc/LDLc, and Cholesterol Retention Factor (CRF).