T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo

• Published in: The Journal of immunology (1950) Vol. 136; no. 3; pp. 823 - 829
• Main Authors: Hayglass, KT, Naides, SJ, Scott, CF, Jr, Benacerraf, B, Sy, MS
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Assoc Immnol 01.02.1986; American Association of Immunologists
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Animals; Antibodies, Anti-Idiotypic - physiology; Antigen-Presenting Cells - immunology; B-Lymphocytes - immunology; Biological and medical sciences; Cell interactions; Cytotoxicity, Immunologic; Epitopes - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hypersensitivity, Delayed - immunology; Immunobiology; Immunoglobulin M - physiology; Leukocyte Count; Lymphocyte Activation; Lymphopenia - immunology; Mice; Mice, Inbred BALB C; p-Azobenzenearsonate - immunology; Rabbits; Rats; Rats, Inbred Lew; T-Lymphocytes - immunology; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Helper-Inducer - immunology; Antigen presentation; Cell-cell interaction; Deficiency; Rodentia; Cytotoxicity; Activation; Delayed hypersensitivity; B»-Lymphocyte; In vivo; Vertebrata; Mammalia; Mouse; T-Lymphocyte
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.136.3.823

B cell-deficient, rabbit anti-mouse IgM-treated mice were compared with normal or normal rabbit immunoglobulin-treated controls in their ability to develop proliferative T cell responses, delayed hypersensitivity, and primary or secondary cytotoxic T cell responses. Immunization with hapten-coupled autologous spleen cells resulted in anti-mu-treated mice generating only marginal T cell responses. This decreased responsiveness was shown to be attributable not to an intrinsic T cell defect or to changes in the ability of macrophages from anti-mu-treated mice to present soluble antigen, but rather to the greatly diminished capacity of B cell-deficient spleen cells to present antigen. The results support the concept that B cells play a significant role in antigen presentation required for T cell activation.