Characterizing Frontal Lobe Seizure Semiology in Children

• Published in: Annals of neurology Vol. 95; no. 6; pp. 1138 - 1148
• Main Authors: van Dalen, Thijs, Kirkham, Jessica F, Chari, Aswin, D'Arco, Felice, Moeller, Friederike, Eltze, Christin, Cross, J Helen, Tisdall, Martin M, Thornton, Rachel C
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2024
• Subjects: Adolescent; Age; Child; Child, Preschool; Children; Convulsions & seizures; Deviation; EEG; Electroencephalography - methods; Epilepsy; Epilepsy, Frontal Lobe - diagnosis; Epilepsy, Frontal Lobe - physiopathology; Epilepsy, Frontal Lobe - surgery; Female; Frontal lobe; Frontal Lobe - physiopathology; Humans; Infant; Male; Patients; Pediatrics; Retrospective Studies; Seizures; Seizures - diagnosis; Seizures - physiopathology; Seizures - surgery; Semiotics; Surgery; Video Recording - methods
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.26922

The objective was to analyze seizure semiology in pediatric frontal lobe epilepsy patients, considering age, to localize the seizure onset zone for surgical resection in focal epilepsy. Fifty patients were identified retrospectively, who achieved seizure freedom after frontal lobe resective surgery at Great Ormond Street Hospital. Video-electroencephalography recordings of preoperative ictal seizure semiology were analyzed, stratifying the data based on resection region (mesial or lateral frontal lobe) and age at surgery (≤4 vs >4). Pediatric frontal lobe epilepsy is characterized by frequent, short, complex seizures, similar to adult cohorts. Children with mesial onset had higher occurrence of head deviation (either direction: 55.6% vs 17.4%; p = 0.02) and contralateral head deviation (22.2% vs 0.0%; p = 0.03), ictal body-turning (55.6% vs 13.0%; p = 0.006; ipsilateral: 55.6% vs 4.3%; p = 0.0003), and complex motor signs (88.9% vs 56.5%; p = 0.037). Both age groups (≤4 and >4 years) showed hyperkinetic features (21.1% vs 32.1%), contrary to previous reports. The very young group showed more myoclonic (36.8% vs 3.6%; p = 0.005) and hypomotor features (31.6% vs 0.0%; p = 0.003), and fewer behavioral features (36.8% vs 71.4%; p = 0.03) and reduced responsiveness (31.6% vs 78.6%; p = 0.002). This study presents the most extensive semiological analysis of children with confirmed frontal lobe epilepsy. It identifies semiological features that aid in differentiating between mesial and lateral onset. Despite age-dependent differences, typical frontal lobe features, including hyperkinetic seizures, are observed even in very young children. A better understanding of pediatric seizure semiology may enhance the accuracy of onset identification, and enable earlier presurgical evaluation, improving postsurgical outcomes. ANN NEUROL 2024;95:1138-1148.