Superhaptens and their potential role in contact dermatitis

Allergic contact dermatitis occurs with increasing incidence and is a common environmental health problem. The undesirable immune response is triggered by small molecules denoted as haptens. Known haptens are synthetic or natural compounds that are present in everyday items like cosmetics or textile...

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Bibliographic Details
Published inDrug discovery today. Therapeutic strategies Vol. 4; no. 1; pp. 11 - 17
Main Authors Günther, Stefan, Weiser, Armin A, Ahmed, Jessica, Preissner, Robert
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2007
Subjects
Medical Education
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Summary:Allergic contact dermatitis occurs with increasing incidence and is a common environmental health problem. The undesirable immune response is triggered by small molecules denoted as haptens. Known haptens are synthetic or natural compounds that are present in everyday items like cosmetics or textiles. Certain compounds (‘superhaptens’) are of particular importance because of their outstanding immunogenic potential. In this article, the processes underlying such hypersensitivities are summarized and therapeutic options will be discussed.
ISSN:1740-6773
1740-6773
DOI:10.1016/j.ddstr.2007.08.003