Changes in mast cell phenotype in rat lung following infection with Nippostrongylus brasiliensis

Previous studies by ourselves and others have shown that mast cells may undergo functional changes in the course of allergic and inflammatory disease. Infection of the rat with the nematode parasite Nippostrongylus brasiliensis leads to an acute inflammatory response in the lung and intestine of the...

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Bibliographic Details
Published inInflammation research Vol. 49 Suppl 1; no. S1; pp. S19 - S20
Main Authors Yue, S C, Pearce, F L
Format Journal Article
LanguageEnglish
Published Switzerland 01.04.2000
Subjects
Animals
Antibodies, Anti-Idiotypic - pharmacology
Histones - pharmacology
Immunoglobulin E - immunology
Ionophores - pharmacology
Lung - pathology
Male
Mast Cells - immunology
Mast Cells - pathology
Nippostrongylus
Nippostrongylus brasiliensis
p-Methoxy-N-methylphenethylamine - pharmacology
Phenotype
Pneumonia - parasitology
Pneumonia - pathology
Polymyxin B - pharmacology
Rats
Rats, Sprague-Dawley
Strongylida Infections - pathology
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Summary:Previous studies by ourselves and others have shown that mast cells may undergo functional changes in the course of allergic and inflammatory disease. Infection of the rat with the nematode parasite Nippostrongylus brasiliensis leads to an acute inflammatory response in the lung and intestine of the animal. We have now used this as a model system and have compared the properties of mast cells recovered from the peritoneum and by enzymatic dissociation of the lung, mesentery and prostate of normal and sensitised animals.
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ISSN:1023-3830
DOI:10.1007/pl00000163