Loss of Gs α impairs liver regeneration through a defect in the crosstalk between cAMP and growth factor signaling

• Published in: Journal of hepatology Vol. 64; no. 2; pp. 342 - 351
• Main Authors: Lu, Changli, Xia, Jie, Zhou, Yongjie, Lu, Xufeng, Zhang, Lei, Gou, Maling, Li, Lei, Zhang, Xiaoyun, Ji, Hongjie, Zhu, Keting, Li, Li, Zhang, Jie, Yu, Ping, Yang, Jiayin, Bu, Hong, Shi, Yujun
• Format: Journal Article
• Language: English
• Published: Netherlands 01.02.2016
• Subjects: Animals; Cell Proliferation - physiology; Cyclic AMP - metabolism; Cyclin-Dependent Kinase 2 - metabolism; Gastroenterology and Hepatology; Genes, cdc - physiology; GTP-Binding Protein alpha Subunits, Gs - genetics; GTP-Binding Protein alpha Subunits, Gs - metabolism; Hepatocytes - metabolism; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Liver Regeneration - physiology; MAP Kinase Signaling System - physiology; Mice; Mice, Knockout; Signal Transduction - physiology; retinoblastoma protein; extracellular signal-regulated kinase; JNK; G-protein-coupled receptor; CDK; cAMP; Rb; the stimulatory G protein α subunit; CREB; cAMP-responsive element-binding protein; MAPK/Erk; Cyclin E; protein kinase A; partial hepatectomy; G1/S transition; PKA; Rb/E2F1; carbon tetrachloride; MAPK; c-Jun N-terminal kinases; CCl 4; cyclic adenosine monophosphate; mitogen-activated protein kinases; G sα; CDK2; PH; GPCR; cyclin-dependent kinase; Erk
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2015.08.036

Graphical abstract