Adenine nucleotide concentrations and energy charge in muscle of chronic haemodialysis patients

Adenine nucleotide concentrations and energy charge ratios were measured in muscle samples collected during transplant surgery of 7 patients suffering from chronic renal failure and undergoing haemodialysis. The energy charge ratio of 0.75 in the muscle of transplant patients was significantly lower...

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Bibliographic Details
Published inNephron (2015) Vol. 60; no. 2; p. 232
Main Authors Cleminson, W G, Manchester, K L, Diesel, W J, Margolius, L P
Format Journal Article
LanguageEnglish
Published Switzerland 1992
Subjects
Adenine Nucleotides - analysis
Adenine Nucleotides - metabolism
Adenosine Diphosphate - analysis
Adenosine Monophosphate - analysis
Adolescent
Adult
Energy Metabolism - physiology
Exercise - physiology
Female
Humans
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Male
Middle Aged
Muscles - chemistry
Muscles - metabolism
Muscles - physiology
Renal Dialysis
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Summary:Adenine nucleotide concentrations and energy charge ratios were measured in muscle samples collected during transplant surgery of 7 patients suffering from chronic renal failure and undergoing haemodialysis. The energy charge ratio of 0.75 in the muscle of transplant patients was significantly lower (p less than 0.01) than that of 0.89 found in muscle from controls. The lower energy charge ratio and increased concentrations of adenosine diphosphate and adenosine monophosphate may contribute to the patients' reduced exercise ability and their poor metabolic state.
ISSN:1660-8151
DOI:10.1159/000186745