The enzymatic oxidation of cysteine to cysteinesulfinate in rat liver

Cysteinesulfinate is considered to be an important intermediate in the catabolism of cysteine and cystine but very little is known about the mechanism of the in vivo oxidation of cysteine to cysteine-sulfinate. We have been interested in the mechanism of biological oxidation of cysteine in connectio...

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Published inBiochemical and biophysical research communications Vol. 18; no. 3; pp. 359 - 363
Main Authors Sörbo, Bo, Ewetz, Lena
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 03.02.1965
Subjects
Chromatography
Cysteine
Electrophoresis
Hydroxylamines
Liver - enzymology
Liver - physiology
Liver Extracts
Metabolism
NADP
Old Medline
Oxidation-Reduction
Pharmacology
Rats
Sulfinic Acids
HYDROXYLAMINES
LIVER EXTRACTS
EXPERIMENTAL LAB STUDY
RATS
CYSTEINE
CHROMATOGRAPHY
SULFINIC ACIDS
LIVER ENZYMOLOGY
ELECTROPHORESIS
METABOLISM
PHARMACOLOGY
HOMOGENATES
NADP
LIVER FUNCTION
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Summary:Cysteinesulfinate is considered to be an important intermediate in the catabolism of cysteine and cystine but very little is known about the mechanism of the in vivo oxidation of cysteine to cysteine-sulfinate. We have been interested in the mechanism of biological oxidation of cysteine in connection with studies on the metabolism of sulfur containing radioprotective agents. The present paper reports an assay system for the enzyme system responsible for the oxidation of cysteine to cysteinesulfinate and its co-factor requirements.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(65)90714-X