The pathology of colorectal polyps and cancers (including biopsy)

Abstract An understanding of the pathology of colorectal polyps and cancers is necessary in order to deliver the most appropriate therapy and devise effective screening programmes that reduce morbidity and mortality. We discuss the classification of polyps occurring in the colon and rectum, focussin...

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Bibliographic Details
Published inSurgery (Oxford) Vol. 32; no. 4; pp. 165 - 171
Main Authors Mohamed, Mustafa, Schofield, John B
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2014
Subjects
Adenoma
carcinoma
colon
endoscopy
histopathology
NHS Bowel Cancer Screening Programme
polyp
Surgery
NHS Bowel Cancer Screening Programme
carcinoma
colon
histopathology
endoscopy
polyp
Adenoma
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Summary:Abstract An understanding of the pathology of colorectal polyps and cancers is necessary in order to deliver the most appropriate therapy and devise effective screening programmes that reduce morbidity and mortality. We discuss the classification of polyps occurring in the colon and rectum, focussing on morphology and molecular pathology, with particular reference to the adenoma-carcinoma sequence and the serrated pathway of colorectal neoplasia. Knowledge of the normal structure of the large bowel is important to understanding the pathogenesis of colorectal polyps and the staging systems that are required for determining prognosis and therapy in colorectal cancer.
ISSN:0263-9319
1878-1764
DOI:10.1016/j.mpsur.2014.02.004