Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry

Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting‐group‐free synthesis using organolithium compounds...

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Bibliographic Details
Published inAngewandte Chemie Vol. 127; no. 6; pp. 1934 - 1938
Main Authors Nagaki, Aiichiro, Imai, Keita, Ishiuchi, Satoshi, Yoshida, Jun-ichi
Format Journal Article
LanguageEnglish
German
Published Weinheim WILEY-VCH Verlag 02.02.2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemoselektivität
Flash-Chemie
Micromixing
Microreactors
Mikroreaktoren
Organolithium compounds
Organolithiumverbindungen
Strömungschemie
Synthesis
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Summary:Flash chemistry using flow microreactors enables highly chemoselective reactions of difunctional electrophiles with functionalized aryllithium compounds by virtue of extremely fast micromixing. The approach serves as a powerful method for protecting‐group‐free synthesis using organolithium compounds and opens a new possibility in the synthesis of polyfunctional organic molecules. Flash‐Chemie in Mikroströmungsreaktoren ermöglicht hoch chemoselektive Reaktionen difunktioneller Elektrophile mit funktionalisierten Aryllithiumverbindungen durch extrem schnelles Mikromischen. Der Ansatz dient als leistungsfähige Methode für die schutzgruppenfreie Synthese unter Verwendung von Organolithiumverbindungen.
Bibliography:ArticleID:ANGE201410717
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This work was partially supported by the Grant-in-Aid for Scientific Research (S) (no. 26220804) and Scientific Research (B) (no. 26288049)
This work was partially supported by the Grant‐in‐Aid for Scientific Research (S) (no. 26220804) and Scientific Research (B) (no. 26288049)
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ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201410717