Effect of Alcoholic Extract of the Plant Conyza bonariensis on the Parasite Hymenolepis nana in Albino Mice Infected with it Experimentally

• Published in: IOP conference series. Earth and environmental science Vol. 1325; no. 1; pp. 12026 - 12034
• Main Authors: Shahatha, S S, Mousa, M O, Ayyed, I M, Outhman, N Y, Dhulkefl, A J, Othman, O M, Mukhlif, F H
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.04.2024
• Subjects: Albinism; Albino mice; Alcoholic extract; Conyza bonariensis; Distilled water; Drugs; Endoparasites; Hymenolepis nana; Niclosamide; Parasites; Plant extracts
• ISSN: 1755-1307; 1755-1315
• DOI: 10.1088/1755-1315/1325/1/012026

Abstract This study was conducted to investigate the effect of an alcoholic extract of the Mountain grass plant Conyza bonariensis on adults of the dwarf tapeworm Hymenolepis nana in albino mice infected with it experimentally, where Albino mice of the strain Balb/C were infected with these worms experimentally, it was divided into 5 groups, each group consisting of 6 rats, where the first group (control) was given distilled water only. As for the other groups, they were dosed with different concentrations of the alcoholic extract of the plant 50, 100, and 200 mg/kg, The last group was given 15 mg/kg of Niclosamide in one dose per day for 13 days. The results showed the effective effect of the concentrations of the alcoholic extract and the drug Niclosamide in the treatment of albino mice, and it produced a high therapeutic efficiency of 100%, with a variation in the period required for complete treatment and complete elimination of helminths, where the highest concentration of 200 mg/kg and the use of the drug led to a complete recovery of the infected Albino mice during the ninth day of treatment, and it was noted that the worm eggs disappeared from the swabs of the treated mice, while the infection continued in the control group until the thirteenth day, then died after that.