Cluster analysis identifies quantitative CT imaging-based subgroups in COPD subjects with pulmonary artery enlargement

Pulmonary hypertension (PH) affects up to 60% of patients with COPD [1, 2]. When present, COPD-PH is a high-risk finding with associated mortality of up to 40% at 5 years [1, 3]. This mortality risk is multifactorial and in part reflects significant disease heterogeneity, which has limited the abili...

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Published inThe European respiratory journal Vol. 66; no. 2; p. 2500038
Main Authors Johnson, Shelsey W., Ross, James C., Nardelli, Pietro, Choi, Bina, Vanderpool, Rebecca R., Pistenmaa, Carrie, Wells, J. Michael, San Jose Estépar, Raul, Washko, George, Rahaghi, Farbod N.
Format Journal Article
LanguageEnglish
Published England European Respiratory Society 01.08.2025
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Research Letter
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Summary:Pulmonary hypertension (PH) affects up to 60% of patients with COPD [1, 2]. When present, COPD-PH is a high-risk finding with associated mortality of up to 40% at 5 years [1, 3]. This mortality risk is multifactorial and in part reflects significant disease heterogeneity, which has limited the ability to identify effective treatments [4, 5]. Disease heterogeneity in COPD-PH has limited the ability to identify effective treatments. Chest CT is a non-invasive tool to advance disease sub-phenotyping. In COPDGene, cluster analysis identifies CT-based subgroups with differential mortality risk. https://bit.ly/4jEy5RT
Bibliography:content type line 23
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
ISSN:0903-1936
1399-3003
1399-3003
DOI:10.1183/13993003.00038-2025