Dissolution of bone by macrophages adhered on bone tissue

We investigated the solubilization of bone tissue by macrophages, in terms of lactate production in vitro using bone particles which could not be engulfed by macrophages. The conditions during contact to bone tissue and phagocytosis were observed ultrastructurally. The results indicated that macroph...

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Bibliographic Details
Published inJapanese Journal of Oral Biology Vol. 27; no. 2; pp. 562 - 568
Main Authors Hashimoto, Yoshikazu, Yabuta, Hiroko, Miyazawa, Chyuzo, Saito, Ritsuko
Format Journal Article
LanguageEnglish
Published Japanese Association for Oral Biology 1985
Subjects
bone dissolution
lactate
macrophages
morphology
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Summary:We investigated the solubilization of bone tissue by macrophages, in terms of lactate production in vitro using bone particles which could not be engulfed by macrophages. The conditions during contact to bone tissue and phagocytosis were observed ultrastructurally. The results indicated that macrophages have soluble action to bone tissue when in contact with the tissue, as suggested by release of Ca, lactate production, rise of lactate dehydrogenase-activity and glucose consumption by macrophages. Significant correlation was also found between production of lactate by macrophages and Ca releases from bone tissue. Electron microscopic observation suggests that macrophages can dissolve bone particles which can then be phagocytized following destruction and solubilization of bone tissue.
ISSN:0385-0137
DOI:10.2330/joralbiosci1965.27.562