Thymosin α1 Stimulates Endothelial Cell Migration, Angiogenesis, and Wound Healing

Abstract In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin α1 (Tα1) on endothelial cell migration, angiogenesis, and wound healing....

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Published inThe Journal of immunology (1950) Vol. 160; no. 2; pp. 1001 - 1006
Main Authors Malinda, Katherine M., Sidhu, Gurmel S., Banaudha, Krishna K., Gaddipati, Jaya P., Maheshwari, Radha K., Goldstein, Allan L., Kleinman, Hynda K.
Format Journal Article
LanguageEnglish
Published 15.01.1998
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Summary:Abstract In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin α1 (Tα1) on endothelial cell migration, angiogenesis, and wound healing. Tα1, a 28 amino acid peptide initially isolated from the thymus, enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro. In vivo, Tα1 stimulated angiogenesis in a subcutaneous model. When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Tα1 promotes angiogenesis and wound healing.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.160.2.1001