Thymic tumors induced by 3-methylcholanthrene treatment of rat Peyer's patches
Studies were performed to characterize thymic tumors which were induced after a single injection of 500 μg or 3-methylcholanthrene (3-MC) into surgically exposed Peyer's patches (PP) of Copenhagen rats. Detailed gross, histological, and morphological analyses revealed thymic tumors differing in...
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Published in | Experimental and molecular pathology Vol. 54; no. 1; pp. 47 - 60 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.02.1991
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Subjects | |
Online Access | Get full text |
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Summary: | Studies were performed to characterize thymic tumors which were induced after a single injection of 500 μg or 3-methylcholanthrene (3-MC) into surgically exposed Peyer's patches (PP) of Copenhagen rats. Detailed gross, histological, and morphological analyses revealed thymic tumors differing in size and weight (1 to > 8 g) with distorted architecture and infiltration by lymphocytes and epithelial cells in varying proportions. Approximately 25% of the rats with thymic tumors exhibited abnormal spleens, whereas 66% developed low grade leukemias. A majority of the thymic tumors contained cells which exhibited (1) phenotypic markers characteristic of normal thymocytes, (2) abnormal DNA, and (3) increased percentages in S + G
2 phases of the cell cycle. Further studies of tumor cell isolates demonstrated an increased frequency of colony formation on soft agar, as well as the ability to elicit thymic tumors upon transplantation. Collectively these studies describe chemically induced thymic lymphomas. |
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ISSN: | 0014-4800 1096-0945 |
DOI: | 10.1016/0014-4800(91)90043-W |