Effects of cholecystokinin peptides on digestive enzymes in killifish in vivo

1. 1. The abilities of cholecystokinin-like peptides to elicit lipase secretion were examined in the stomachless killifish, Fundulus heteroclitus. 2. 2. Cholecystokinin octapeptide, caerulein, and nonsulfated caerulein stimulated lipase secretion in vivo, with caerulein and nonsulfated caerulein bei...

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Published inComparative biochemistry and physiology. A, Comparative physiology Vol. 89; no. 4; pp. 655 - 660
Main Authors Honkanen, R.E, Crim, J.W, Patton, J.S
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 1988
Subjects
Animals
Atropine - pharmacology
Bile - drug effects
Bile - metabolism
Carbachol - metabolism
Ceruletide - pharmacology
Cyprinodontiformes - physiology
Killifishes - physiology
Kinetics
Lipase - metabolism
Lipolysis - drug effects
Sincalide - pharmacology
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Summary:1. 1. The abilities of cholecystokinin-like peptides to elicit lipase secretion were examined in the stomachless killifish, Fundulus heteroclitus. 2. 2. Cholecystokinin octapeptide, caerulein, and nonsulfated caerulein stimulated lipase secretion in vivo, with caerulein and nonsulfated caerulein being the most potent peptides tested. 3. 3. Lipase secretion was not induced by carbachol, and peptide stimulated lipase secretion was not inhibited by atropine. 4. 4. These data suggest digestive enzyme secretion constitutes an evolutionary primitive role for CCK.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0300-9629
DOI:10.1016/0300-9629(88)90849-3