Soft tissue sarcoma of the upper extremity: A 5-year experience at two institutions emphasizing the role of soft tissue flap reconstruction

• Published in: Cancer Vol. 94; no. 8; pp. 2256 - 2264
• Main Authors: LOHMAN, Robert F, NABAWI, Ayman S, REECE, Gregory P, POLLOCK, Raphael E, EVANS, Gregory R. D
• Format: Conference Proceeding Journal Article
• Language: English
• Published: New York, NY Wiley-Liss 15.04.2002
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Child; Combined Modality Therapy; Extremities - surgery; Female; Humans; Leg Bones - surgery; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local - radiotherapy; Neoplasm Recurrence, Local - surgery; Neoplasm Staging; Postoperative Complications; Reconstructive Surgical Procedures; Sarcoma - radiotherapy; Sarcoma - surgery; Skin plastic surgery; Soft Tissue Neoplasms - radiotherapy; Soft Tissue Neoplasms - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgical Flaps; Treatment Outcome; Human; Plasty; Treatment; Sarcoma; Surgery; Complication; Upper limb; Soft tissue; Malignant tumor; Flap (surgery)
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.10419

The objective of this study was to define the impact of soft tissue flap reconstruction on multimodality therapy for patients with soft tissue sarcomas of the upper extremity. Treatment standards continue to evolve for these patients, and, with multimodality therapy, most of them are candidates for limb-preserving surgery. Consequently, the role of soft tissue flap reconstruction is expanding. A review was conducted of 100 consecutive patients with soft tissue sarcomas of the upper extremity who underwent surgery at several institutions between 1992 and 1997. Seventy-one patients underwent direct closure of defects after tumor resection, and 29 patients required soft tissue reconstruction with flaps. These groups were similar in most respects, except that 52% of the patients who required soft tissue reconstruction presented with recurrent disease (P = 0.0004), and 79% of them had tumors measuring > 5 cm in greatest dimension (P = 0.0003). The patients who required flap reconstruction had larger skin deficits after undergoing tumor resection (140 cm2) compared with the patients who had wounds that were managed by direct closure (40 cm2; P < 0.00001). Margins around the resected tumors were larger (1.62 cm) when flaps were employed compared with margins when defects were closed directly (0.87 cm; P = 0.0005). However, the number of patients with intralesional, marginal, wide, and radical resections was the same regardless of wound management. Major complications occurred in 14% of patients, but none led to death or amputation. The median follow-up was 31 months, and 66% of patients had no evidence of disease at that time. Rates of local recurrence and survival were similar for patients who underwent flap reconstruction compared with patients who underwent direct closure. Soft tissue flap reconstruction facilitates therapy for patients with soft tissue sarcomas of the upper extremity, so that patients with larger tumors can undergo resection, limiting complications and limb sacrifice.