Molecular mobility in hydrogels based on poly(acrylic acid) and macrodiisocyanates

Partially water-swellable polymer networks were synthesized on the basis of poly(acrylic acid) and various macrodiisocyanates. Hydrophilic and hydrophobic local regions were revealed in swollen networks (hydrogels) by means of the spin probe technique. The local mobility in hydrophobic regions depen...

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Published inPolymer Science. Series A Vol. 48; no. 12; pp. 1304 - 1309
Main Authors Baranovskii, V. Yu, Yasina, L. L., Motyakin, M. V., Aliev, I. I., Shenkov, S., Dimitrov, M., Lambov, N., Wasserman, A. M.
Format Journal Article
LanguageEnglish
Published Oxford Springer Nature B.V 01.12.2006
Subjects
Acrylics
Chemical industry
Hydrogels
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Summary:Partially water-swellable polymer networks were synthesized on the basis of poly(acrylic acid) and various macrodiisocyanates. Hydrophilic and hydrophobic local regions were revealed in swollen networks (hydrogels) by means of the spin probe technique. The local mobility in hydrophobic regions depends on the macrodiisocyanate structure; however, it is substantially lower than that in hydrophilic regions for all gels. It was assumed that the presence of hydrophobic and hydrophilic regions and the difference in their local dynamics must have a substantial effect on the pharmacokinetics of release of drugs immobilized in these hydrogels.[PUBLICATION ABSTRACT]
ISSN:0965-545X
1555-6107
DOI:10.1134/S0965545X0612011X