Two Cases of Cutaneous Apocrine Ductal Carcinoma of the Axilla

We report 2 cases of cutaneous apocrine ductal carcinoma (CADC) of the axilla in a 64- and a 54-year-old male. Histological examination revealed 2 solid, ductal and glandular tumors with decapitation secretion. Tumor cells showed cellular and nuclear atypism, and infiltrative growth of tumor cell ne...

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Bibliographic Details
Published inDermatology (Basel) Vol. 199; no. 4; pp. 332 - 337
Main Authors Katagiri, Y., Ansai, S.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.01.1999
Subjects
Case Report
Immunohistochemistry
Ultrastructure
Apocrine skin carcinoma
Apocrine adenocarcinoma
Cutaneous apocrine ductal carcinoma
Apocrine ductal carcinoma
Apocrine carcinoma
Sweat gland neoplasm
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Summary:We report 2 cases of cutaneous apocrine ductal carcinoma (CADC) of the axilla in a 64- and a 54-year-old male. Histological examination revealed 2 solid, ductal and glandular tumors with decapitation secretion. Tumor cells showed cellular and nuclear atypism, and infiltrative growth of tumor cell nests was also observed. Although there were no characteristic features of extramammary Paget’s disease on the overlying skin, case 1 exhibited a typical Paget’s phenomenon. We concluded that the Paget’s phenomenon of case 1 was a result of upward extension of the tumor in the dermis. The neoplastic cells of both cases were immunohistochemically positive for gross cystic disease fluid protein, lysozyme, CD15 and carcinoembryonic antigen but negative for S-100 protein. Based on these findings, we concluded that these tumors were cutaneous apocrine ductal carcinomas. There was no evidence of tumor remnants in the axilla, and the patients have shown no signs of local recurrence or metastasis. We also reviewed the literature and summarize here the clinical features of CADC.
ISSN:1018-8665
1421-9832
DOI:10.1159/000018285