Chemokines, chemokine receptors, and renal disease : From basic science to pathophysiologic and therapeutic studies

• Published in: Journal of the American Society of Nephrology Vol. 11; no. 1; pp. 152 - 176
• Main Authors: SEGERER, S, NELSON, P. J, SCHLÖNDORFF, D
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 2000
• Subjects: Acute Disease; Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Chemokines - classification; Chemokines - physiology; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Humans; Inflammation - physiopathology; Kidney Diseases - diagnosis; Kidney Diseases - physiopathology; Kidney Diseases - therapy; Protein hormones. Growth factors. Cytokines; Proteins; Receptors, Chemokine - physiology; Sensitivity and Specificity; Chemokine; Kidney disease; Animal model; Urinary system disease; Receiver; Review; Molecular biology; Mechanism of action
• ISSN: 1046-6673; 1533-3450
• DOI: 10.1681/ASN.V111152

Leukocyte trafficking from peripheral blood into affected tissues is an essential component of the inflammatory reaction to virtually all forms of injury and is an important factor in the development of many kidney diseases. Advances in the past few years have highlighted the central role of a family of chemotactic cytokines called chemokines in this process. Chemokines help to control the selective migration and activation of inflammatory cells into injured renal tissue. Chemokines and their receptors are expressed by intrinsic renal cells as well as by infiltrating cells during renal inflammation. This study summarizes the in vitro and in vivo data on chemokines and chemokine receptors in renal diseases with a special focus on potential therapeutic effects on inflammatory processes.