A Lewis acid-mediated protocol for the protection of aryl amines as their Boc-derivatives

A new protocol of protection of poorly reactive aryl amines and functionalized amines with Boc(2)O in the presence of Zn(ClO4)(2).6H(2)O as the catalyst is reported. The catalytic action of Zn(ClO4)(2).6H(2)O is specific for the activation of the pyrocarbonates, thus acid sensitive functionalities a...

Full description

Saved in:
Bibliographic Details
Published inSynlett no. 10; pp. 1794 - 1798
Main Authors Bartoli, G, Bosco, M, Locatelli, M, Marcantoni, E, Massaccesi, M, Melchiorre, P, Sambri, L
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 09.08.2004
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Lewis acid
zinc perchlorate
ALCOHOLS
ACYLATION
ZN(CLO4)CENTER-DOT-6HO
MG(CLO4)
aryl amines
protection
Boc-derivatives
POWERFUL CATALYST
Online AccessGet more information

Cover

More Information
Summary:A new protocol of protection of poorly reactive aryl amines and functionalized amines with Boc(2)O in the presence of Zn(ClO4)(2).6H(2)O as the catalyst is reported. The catalytic action of Zn(ClO4)(2).6H(2)O is specific for the activation of the pyrocarbonates, thus acid sensitive functionalities and stereochemical configurations of the starting materials remain unaltered in the protection process.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-829059