Monitoring of Isothermal Crystallization and Time–Temperature Transformation of Amorphous Felodipine: The Time-Domain Nuclear Magnetic Resonance Method

The isothermal crystallization process of felodipine has been investigated using the time-domain Nuclear Magnetic Resonance (NMR) method for amorphous bulk and ground samples. The obtained induction and crystallization times were then used to construct the time–temperature-transformation (TTT) diagr...

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Published inAAPS PharmSciTech Vol. 25; no. 7; p. 219
Main Authors Pajzderska, A., Gonzalez, M. A., Jarek, M., Wąsicki, J.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 19.09.2024
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Crystallization - methods
Felodipine - chemistry
Hydrogen Bonding
Magnetic Resonance Spectroscopy - methods
Molecular Dynamics Simulation
Pharmacology/Toxicology
Pharmacy
Research Article
Temperature
Transition Temperature
recrystallization
relaxometry
physical stability
time-domain NMR
TTT diagram
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Summary:The isothermal crystallization process of felodipine has been investigated using the time-domain Nuclear Magnetic Resonance (NMR) method for amorphous bulk and ground samples. The obtained induction and crystallization times were then used to construct the time–temperature-transformation (TTT) diagram, both above and below the glass transition temperature (T g ). The Nose temperature was found equal to 363 K. Furthermore, the dynamics of crystalline and amorphous felodipine were compared across varying temperatures. Molecular dynamics simulations were also employed to explore the hydrogen-bond interactions and dynamic properties of both systems. Graphical Abstract
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ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-024-02919-2