Total body irradiation: Clinical experience at the institute Jules Bordet

Our clinical experience with 58 patients receiving TBI as part of their treatment for a malignant hematopoietic disease suggests the following comments: • 6 daily fractions of 2 Gy given over 6 days have a similar antitumoral effect as a single dose of 10 Gy, using a low dose rate, but with less tox...

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Bibliographic Details
Published inRadiotherapy and oncology Vol. 18; pp. 128 - 131
Main Authors Regnier, R., Piron, A., Debusscher, L., van Houtte, P.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 1990
Subjects
Clinical Protocols
Combined Modality Therapy
Dosimetry
Humans
Late effects
Leukemia - drug therapy
Leukemia - radiotherapy
Leukemia - surgery
Neoplasm Recurrence, Local
Radiation Tolerance
Recurrences
Relapse free survival
Time dose pattern
Total body irradiation
Whole-Body Irradiation - methods
Time dose pattern
Relapse free survival
Late effects
Total body irradiation
Dosimetry
Recurrences
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Summary:Our clinical experience with 58 patients receiving TBI as part of their treatment for a malignant hematopoietic disease suggests the following comments: • 6 daily fractions of 2 Gy given over 6 days have a similar antitumoral effect as a single dose of 10 Gy, using a low dose rate, but with less toxicity. • 7 daily fractions of 2.25 Gy given over 8 days exceed normal lung tolerance. No leukemia recurrence was observed among patients treated with 6 times 2 Gy but the maximal period of observation is only 560 days. On the other hand, a relapse was seen 2 years after 7 times 2.25 Gy. This may suggest the necessity to find a more effective drug regimen or to deliver additional radiation to possible sanctuary sites for chemotherapy.
ISSN:0167-8140
1879-0887
DOI:10.1016/0167-8140(90)90192-Y