Mesenchymal Stem Cell-Derived Exosomes as Drug Delivery Vehicles in Disease Therapy

Exosomes are small vesicles containing proteins, nucleic acids, and biological lipids, which are responsible for intercellular communication. Studies have shown that exosomes can be utilized as effective drug delivery vehicles to accurately deliver therapeutic substances to target tissues, enhancing...

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Published inInternational journal of molecular sciences Vol. 25; no. 14; p. 7715
Main Authors Zhao, Wenzhe, Li, Kaixuan, Li, Liangbo, Wang, Ruichen, Lei, Yang, Yang, Hui, Sun, Leming
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.07.2024
Subjects
Biosynthesis
Cells
Communication
Disease
disease therapy
drug delivery
Endoplasmic reticulum
exosome
Inflammation
Ischemia
Lipids
mesenchymal stem cell
MicroRNAs
nanocarriers
Proteins
mesenchymal stem cell
drug delivery
disease therapy
exosome
nanocarriers
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Summary:Exosomes are small vesicles containing proteins, nucleic acids, and biological lipids, which are responsible for intercellular communication. Studies have shown that exosomes can be utilized as effective drug delivery vehicles to accurately deliver therapeutic substances to target tissues, enhancing therapeutic effects and reducing side effects. Mesenchymal stem cells (MSCs) are a class of stem cells widely used for tissue engineering, regenerative medicine, and immunotherapy. Exosomes derived from MSCs have special immunomodulatory functions, low immunogenicity, the ability to penetrate tumor tissues, and high yield, which are expected to be engineered into efficient drug delivery systems. Despite the promising promise of MSC-derived exosomes, exploring their optimal preparation methods, drug-loading modalities, and therapeutic potential remains challenging. Therefore, this article reviews the related characteristics, preparation methods, application, and potential risks of MSC-derived exosomes as drug delivery systems in order to find potential therapeutic breakthroughs.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25147715