The hemodynamic and embolizing forces acting on thrombi—II. The effect of pulsatile blood flow

A previous analysis (Basmadjian, J. Biomechanics 17, 287–298, 1984) of the embolizing forces acting on thrombi in steady Poiseuille flow has been extended to pulsatile blood flow conditions in the major blood vessels. We show that for incipient and small compact thrombi up to 0.1 mm height, the maxi...

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Bibliographic Details
Published inJournal of biomechanics Vol. 19; no. 10; pp. 837 - 845
Main Author Basmadjian, Diran
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 1986
Subjects
Blood Circulation
Embolism - physiopathology
Hemodynamics
Models, Cardiovascular
Pulse
Thrombosis - physiopathology
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Summary:A previous analysis (Basmadjian, J. Biomechanics 17, 287–298, 1984) of the embolizing forces acting on thrombi in steady Poiseuille flow has been extended to pulsatile blood flow conditions in the major blood vessels. We show that for incipient and small compact thrombi up to 0.1 mm height, the maximum embolizing stresses can be calculated from the corresponding ‘quasi-steady’ viscous drag forces and measured maximum wall shear. Their magnitude is from 5 to 30 times ( τ ω ) Max , the maximum wall shear stress during the cardiac cycle in the absence of thrombi. For larger thrombi, inertial and ‘history’ effects have to be taken into account, leading to embolizing stresses in excess of 100 Pa (1000 dyn cm −2).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9290
1873-2380
DOI:10.1016/0021-9290(86)90134-X