A new approach for quantitative evaluation of cross-reactivity of steroids with an antiserum by radioimmunoassay: Application to a highly specific antiestriol

The study of several antiestriol antisera in the presence of a series of analogues of estriol has led to a critical discussion of the classical cross-reaction test. A more accurate test (CR 1 ng) which permits a more precise determination of specificity of antisera is described.

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Bibliographic Details
Published inSteroids Vol. 22; no. 6; pp. 747 - 761
Main Authors de Lauzon, S., Cittanova, N., Desfosses, B., Jayle, M.F.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.1973
Subjects
Animals
Antibody Specificity
Cross Reactions
Estriol - analysis
Estrone
Immune Sera
Methods
Rabbits - immunology
Radioimmunoassay
Serum Albumin, Bovine
Sheep - immunology
Tritium
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Summary:The study of several antiestriol antisera in the presence of a series of analogues of estriol has led to a critical discussion of the classical cross-reaction test. A more accurate test (CR 1 ng) which permits a more precise determination of specificity of antisera is described.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(73)90050-0