Globular changes in cytomegaloviral inclusions after Ganciclovir treatment

Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.

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Bibliographic Details
Published inArchives of virology Vol. 108; no. 3-4; p. 287
Main Authors Hruban, Z, Kuzo, R, Heimann, P, Weisenberg, E, Hruban, R H
Format Journal Article
LanguageEnglish
Published Austria 01.01.1989
Subjects
Acquired Immunodeficiency Syndrome - complications
Adult
Bone Marrow Transplantation
Capsid - ultrastructure
Cytomegalovirus - drug effects
Cytomegalovirus - ultrastructure
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - etiology
Cytomegalovirus Infections - pathology
DNA, Viral - biosynthesis
DNA, Viral - drug effects
Eosine Yellowish-(YS)
Female
Ganciclovir - therapeutic use
Humans
Kidney Transplantation
Lung - microbiology
Lung - ultrastructure
Male
Pneumonia - drug therapy
Pneumonia - etiology
Postoperative Complications - drug therapy
Postoperative Complications - microbiology
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Summary:Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.
ISSN:0304-8608
DOI:10.1007/BF01310941