Abundance of VIP in duodenal mucosa of coeliacs and duodenal ulcer patients

• Published in: Peptides (New York, N.Y. : 1980) Vol. 5; no. 2; pp. 411 - 413
• Main Authors: Domschke, S., Bloom, S.R., Adrian, T.E., Lux, G., Bryant, M.G., Domschke, W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.1984
• Subjects: Adult; Celiac Disease - metabolism; Coeliac sprue; Duodenal ulcer; Duodenal Ulcer - metabolism; Duodenitis; Duodenum - analysis; Gastric Mucosa - analysis; Gastroduodenal mucosa; Gastrointestinal Diseases - metabolism; Humans; Intestinal Mucosa - analysis; Jejunum - analysis; Organ Specificity; Substance P; Vasoactive intestinal peptide; Vasoactive Intestinal Peptide - analysis; Duodenal ulcer; Gastroduodenal mucosa; Coeliac sprue; Substance P; Duodenitis; Vasoactive intestinal peptide
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/0196-9781(84)90245-6

VIP levels were determined in gastroduodenal mucosal biopsies of 8 duodenal ulcer patients, of 5 coeliac sprue patients, and of 8 volunteers without upper gastrointestinal disease. In duodenal ulcer patients, mucosal VIP concentrations were significantly elevated in the proximal duodenum (e.g., in the duodenal bulb 225±48 versus 95±17 pmol/g in controls), while in coeliac sprue VIP levels tended to be increased in the whole duodenum and upper jejunum (e.g., descending duodenum 409±161 versus 81±16, p<0.05). In both disease entities, the rise in mucosal VIP may be a reaction of the peptidergic nervous system to chronic mucosal irritation and a reason for enhanced fluid and electrolyte secretion in the affected areas.