Small synthetic molecules with antiglycation activity. Structure–activity relationship

The accumulation of advanced glycation end products (AGEs) is currently considered as one of the key factors in aging processes, the pathogenesis of late complications of diabetes mellitus, cancer and neurodegenerative diseases. This review is devoted to small synthetic molecules with antiglycation...

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Bibliographic Details
Published inRussian chemical reviews Vol. 91; no. 6; p. RCR5041
Main Authors Savateev, Konstantin V., Spasov, Alexander A., Rusinov, Vladimir L.
Format Journal Article
LanguageEnglish
Published London Uspekhi Khimii, ZIOC RAS, Russian Academy of Sciences and IOP Publishing Limited 01.07.2022
IOP Publishing
Subjects
Carbon
Chemical reactions
Cross coupling
Diabetes mellitus
Electron transfer
Functional groups
Functional materials
Metal compounds
Molecular structure
Organic compounds
Palladium
Pathogenesis
Single electrons
Toxicity
Transition metal compounds
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Summary:The accumulation of advanced glycation end products (AGEs) is currently considered as one of the key factors in aging processes, the pathogenesis of late complications of diabetes mellitus, cancer and neurodegenerative diseases. This review is devoted to small synthetic molecules with antiglycation activity, i.e., compounds with the ability to inhibit AGE formation. Molecules with antiglycation activity in the low micromolar range (<10 μM), primarily fused heterocyclic systems containing oxygen or nitrogen as heteroatoms and (thio)ureas, have been discovered to date. The known scaffolds with antiglycation activity are analyzed, structural modifications to enhance antiglycation abilities are highlighted and the structure–activity relationships are discussed.The bibliography includes 125 references.
ISSN:0036-021X
1468-4837
DOI:10.1070/RCR5041