TSH adenomas

Thyrotropin (TSH) adenomas are uncommon tumors of the anterior pituitary. Clinically, they may present with hyperthyroidism, hypothyroidism, hypopituitarism, or visual loss. Proper diagnosis requires appropriate neuroendocrine evaluation. Although transsphenoidal surgery remains the first-line treat...

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Bibliographic Details
Published inPituitary Vol. 9; no. 4; pp. 313 - 315
Main Authors Laws, Edward R, Vance, Mary Lee, Jane, Jr, John A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.2006
Subjects
Adenoma - complications
Adenoma - diagnosis
Adenoma - secretion
Adenoma - therapy
Algorithms
Biomarkers - blood
Chemotherapy, Adjuvant
Humans
Hyperthyroidism - etiology
Hypophysectomy
Hypopituitarism - etiology
Hypothyroidism - etiology
Pituitary Neoplasms - complications
Pituitary Neoplasms - diagnosis
Pituitary Neoplasms - secretion
Pituitary Neoplasms - therapy
Radiotherapy, Adjuvant
Thyrotropin - secretion
Treatment Outcome
Vision Disorders - etiology
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Summary:Thyrotropin (TSH) adenomas are uncommon tumors of the anterior pituitary. Clinically, they may present with hyperthyroidism, hypothyroidism, hypopituitarism, or visual loss. Proper diagnosis requires appropriate neuroendocrine evaluation. Although transsphenoidal surgery remains the first-line treatment, adjuvant medical therapy is frequently required for these often invasive tumors. Radiotherapy or radiosurgery should be considered for those patients with persistent TSH hypersecretion following surgery and medical therapy. The clinical evaluation and treatment algorithm for patients with TSH adenomas is discussed.
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ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-006-0411-x