Iron detoxification by haemoperfusion through deferoxamine-conjugated agarose-polyacrolein microsphere beads

The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experimen...

Full description

Saved in:
Bibliographic Details
Published inBiomaterials Vol. 6; no. 1; pp. 9 - 16
Main Authors Horowitz, David, Margel, Shlomo, Shimoni, Tuvia
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 1985
Subjects
Acrolein
Animals
Deferoxamine
Deferoxamine - therapeutic use
Dogs
haemoperfusion
Hemoperfusion - methods
Iron - blood
iron chelation
iron overload
Microspheres
polyacrolein microspheres
Polymers
Rabbits
Sepharose
iron chelation
iron overload
haemoperfusion
Deferoxamine
polyacrolein microspheres
Online AccessGet full text

Cover

More Information
Summary:The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasnu/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(85)90031-6