Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtain...

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Bibliographic Details
Published inNeuroscience letters Vol. 29; no. 3; p. 281
Main Authors Lodge, D, Anis, N A, Burton, N R
Format Journal Article
LanguageEnglish
Published Ireland 26.04.1982
Subjects
Acetylcholine - pharmacology
Action Potentials - drug effects
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - pharmacology
Cats
Ketamine - pharmacology
N-Methylaspartate
Neurons - drug effects
Neurons - physiology
Rats
Spinal Cord - physiology
Stereoisomerism
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Summary:The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtained in anaesthetic and analgesic tests [16, 19, 25].
ISSN:0304-3940
DOI:10.1016/0304-3940(82)90330-5