Drugs and the liver

The liver and its diseases can affect drug metabolism and drugs can modify liver function. Ethanol produces dose dependent liver damage and is the most common cause of cirrhosis. Aspirin has been associated with Reye's syndrome in children, which involves fatty degeneration of the viscera and l...

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Bibliographic Details
Published inAnaesthesia and intensive care medicine Vol. 7; no. 2; pp. 69 - 71
Main Author Pleuvry, Barbara J
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.2006
Subjects
alcohol
aspirin
dysfunction
ethanol
halothane
hepatitis
liver
pharmacology
postoperative
postoperative
alcohol
liver
halothane
pharmacology
aspirin
hepatitis
ethanol
dysfunction
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Summary:The liver and its diseases can affect drug metabolism and drugs can modify liver function. Ethanol produces dose dependent liver damage and is the most common cause of cirrhosis. Aspirin has been associated with Reye's syndrome in children, which involves fatty degeneration of the viscera and liver failure. Most inhalational anaesthetic agents have been associated with postoperative liver dysfunction but much of the literatures concerns halothane. Halothane-associated hepatitis has been attributed to a direct effect of halothane or a metabolite on liver cells, while fulminating hepatic failure has been attributed to an immune reaction following repeat halothane exposure.
ISSN:1472-0299
1878-7584
DOI:10.1383/anes.2006.7.2.69