Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry

Endolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease....

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Published inClinical neuropathology Vol. 43; no. 2; pp. 43 - 47
Main Authors Sun, Wenjia, Wang, Manxiang, Yue, Junqiu
Format Journal Article
LanguageEnglish
Published Germany Dustri - Verlag Dr. Karl Feistle GmbH & Co. KG 01.03.2024
Subjects
Adenoma - pathology
Adult
Bone Neoplasms - pathology
Carcinoma, Renal Cell - diagnosis
Diagnostic Errors
Ear Neoplasms - chemistry
Ear Neoplasms - diagnosis
Ear Neoplasms - pathology
Endolymphatic Sac - chemistry
Endolymphatic Sac - pathology
Humans
Immunohistochemistry
Kidney cancer
Kidney Neoplasms - diagnosis
Kidney Neoplasms - pathology
Male
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Summary:Endolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confirming the absence of renal neoplasm to rule out the possibility of metastasis are critical for obtaining an accurate final diagnosis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0722-5091
DOI:10.5414/NP301603