The possible mode of action of prostaglandins: XVI. A study to assess the local effect of prostaglandins E1, E2 OR F2α in the regulation of male fertility

A single intratesticular injection of prostaglandin E1 (PGE1) or prostaglandin E2 (PGE2) at a dose of 2.5 mg/kg was found to interfere with the fertilizing ability of epididymal spermatozoa of the test animals both in the injected and contralateral control sides. Prostaglandin F2∞( , conversely, was...

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Bibliographic Details
Published inProstaglandins and medicine Vol. 4; no. 6; pp. 465 - 470
Main Authors Rej, S.K., Chatterjee, A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.06.1980
Subjects
Animals
Epididymis - drug effects
Fertility - drug effects
Male
Population
Prostaglandins E - pharmacology
Prostaglandins F - pharmacology
Prostate - drug effects
Rats
Seminal Vesicles - drug effects
Spermatozoa - drug effects
Testis - metabolism
Testosterone - pharmacology
Comparative Studies
Studies
Economic Factors
Prostaglandins
Technology
Men
Biology
Physiology
Research Methodology
Research And Development
Endocrine System
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Summary:A single intratesticular injection of prostaglandin E1 (PGE1) or prostaglandin E2 (PGE2) at a dose of 2.5 mg/kg was found to interfere with the fertilizing ability of epididymal spermatozoa of the test animals both in the injected and contralateral control sides. Prostaglandin F2∞( , conversely, was found to be ineffective in terms of fertility of the test animals in the same experimental model. The beneficial effect of testosterone therapy concurrently with either of the PGE1 or PGE2 in maintaining the fertility of the animals has been recorded and discussed in terms of the mode of action of prostaglandins.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0161-4630
1878-0636
DOI:10.1016/0161-4630(80)90055-5