The low affinity component of [3H]spiperone binding reflects association to a non-dopaminergic, neuroleptic site

The pharmacological properties of a low affinity site labelled by [3H]spiperone in membranes prepared from the rat nucleus accumbens were examined by investigating the ability of dopaminergic agonists, antagonists and various other drugs to displace the binding of 2 nM [3H]spiperone. Neuroleptic dru...

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Bibliographic Details
Published inNeuroscience letters Vol. 29; no. 2; p. 147
Main Authors Beart, P M, Krstich, M, McDonald, D, Gundlach, A L
Format Journal Article
LanguageEnglish
Published Ireland 16.04.1982
Subjects
Animals
Antipsychotic Agents - metabolism
Binding, Competitive
Butyrophenones - metabolism
Nucleus Accumbens - metabolism
Rats
Receptors, Dopamine - metabolism
Receptors, Drug - metabolism
Septal Nuclei - metabolism
Spiperone - metabolism
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Summary:The pharmacological properties of a low affinity site labelled by [3H]spiperone in membranes prepared from the rat nucleus accumbens were examined by investigating the ability of dopaminergic agonists, antagonists and various other drugs to displace the binding of 2 nM [3H]spiperone. Neuroleptic drugs were the most potent displacers of binding, and dopaminergic agonists, except for bromocryptine and lergotrile, had inhibition constants greater than 1 microM. The majority of drugs studied exhibited a high selectivity for the high affinity site labelled by [3H]spiperone and low affinity sites probably represent a non-specific, non-dopaminergic site for neuroleptic drugs.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(82)90344-5