Malignancies and atherosclerotic plaque diagnosis—is laser induced fluorescence spectroscopy the ultimate solution?

A non-invasive diagnostic tool that can identify diseased tissue sites in situ and in real time could have a major impact on the detection and treatment of cancer and atherosclerosis. A review of the research performed on the utilization of laser induced fluorescence spectroscopy (LIFS) as a means o...

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Bibliographic Details
Published inJournal of Photochemistry & Photobiology, B: Biology Vol. 28; no. 1; pp. 3 - 11
Main Author Papazoglou, Theodore G.
Format Book Review Journal Article
LanguageEnglish
Published Switzerland Elsevier B.V 01.04.1995
Subjects
Arteriosclerosis - diagnosis
Arteriosclerosis - pathology
Atherosclerosis
Cancer
Clinical Trials as Topic
Detection
Dihematoporphyrin Ether - therapeutic use
fluorescence
Humans
Lasers
Neoplasms - diagnosis
Neoplasms - pathology
Spectrometry, Fluorescence - methods
Detection
fluorescence
Atherosclerosis
Cancer
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Summary:A non-invasive diagnostic tool that can identify diseased tissue sites in situ and in real time could have a major impact on the detection and treatment of cancer and atherosclerosis. A review of the research performed on the utilization of laser induced fluorescence spectroscopy (LIFS) as a means of diseased tissue diagnosis is presented. Special emphasis is given to problems which were raised during clinical trials and recent experimental studies. The common origin and possible solution of these problems are shown to be related to, firstly, the identification of the fluorescent chemical species, secondly, the determination of the excitation/collection geometry and its effect to the method and, finally, the further elaboration on the laser-tissue interaction.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1011-1344
1873-2682
DOI:10.1016/1011-1344(95)07126-M