Thiocarbonyl‐Directed Iridium‐Catalyzed C−H Silylation of Indoles and Pyrroles with Hydrosilanes

Herein, hydrogen‐acceptor‐free C2‐selective iridium‐catalyzed C−H silylation of indoles and pyrroles with hydrosilanes via C(sp2)−H bond activation to generate the desired silylated products is presented. The developed protocol allows for the C−H silylation of a wide range of functionalized indoles...

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Published inAdvanced synthesis & catalysis Vol. 367; no. 3
Main Authors Cheng, Yi, Zhan, Jingyi, Wang, Lei, Teng, Houyun, Xu, Li‐Wen, Yang, Lei
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 04.02.2025
Subjects
Catalysis
C−H functionalization
Hydrogen bonds
Hydrosilanes
Indoles
Iridium
Pyrroles
Thiocarbonyl
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Summary:Herein, hydrogen‐acceptor‐free C2‐selective iridium‐catalyzed C−H silylation of indoles and pyrroles with hydrosilanes via C(sp2)−H bond activation to generate the desired silylated products is presented. The developed protocol allows for the C−H silylation of a wide range of functionalized indoles with monohydrosilanes under iridium catalysis. Significantly, this process represents a rare silylation of C−H bonds using S‐directing groups.
Bibliography:These authors contributed equally to this work.
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400903