Positive Remodeling of the Coronary Arteries Detected by Magnetic Resonance Imaging in an Asymptomatic Population

• Published in: Journal of the American College of Cardiology Vol. 53; no. 18; pp. 1708 - 1715
• Main Authors: Miao, Cuilian, MD, Chen, Shaoguang, MS, Macedo, Robson, MD, Lai, Shenghan, MD, Liu, Kiang, MD, Li, Debiao, PhD, Wasserman, Bruce A., MD, Vogel-Clausen, Jens, MD, Lima, João A.C., MD, Bluemke, David A., MD, PhD
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 05.05.2009; Elsevier Limited
• Subjects: Cardiology; Cardiovascular; Cholesterol; coronary artery disease; Coronary vessels; Internal Medicine; magnetic resonance imaging; Medical imaging; NMR; Nuclear magnetic resonance; plaque; subclinical atherosclerosis; United States > US; Baltimore Maryland; Chicago Illinois; coronary artery disease; LM; magnetic resonance imaging; plaque; coronary artery calcium; MRI; left anterior descending coronary artery; LV; subclinical atherosclerosis; magnetic resonance angiogram; multidetector computed tomography; left ventricle/ventricular; 3-dimensional; computed tomography; CAC; CAD; MDCT; LAD; right coronary artery; 3D; CT; IMT; intima-media thickness; RCA; left main coronary artery; magnetic resonance image/imaging; MRA
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2008.12.063

Objectives The purpose of this study was to assess coronary arterial remodeling as a marker of subclinical atherosclerosis using coronary wall magnetic resonance imaging (MRI) in an asymptomatic population-based cohort. Background In early atherosclerosis, compensatory enlargement of both the outer wall of the vessel as well as the lumen, termed compensatory enlargement or positive remodeling, occurs before luminal narrowing. Methods One hundred seventy-nine participants in the MESA (Multi-Ethnic Study of Atherosclerosis) trial were evaluated using black-blood coronary wall MRI. Coronary cross-sectional area (vessel size), lumen area, and mean wall thickness of the proximal coronary arteries were measured. Results Men had a greater vessel size, lumen area, and mean wall thickness than women (38.3 ± 11.3 mm2 vs. 32.6 ± 9.4 mm2 , 6.7 ± 3.2 mm2 vs. 5.3 ± 2.4 mm2 , and 2.0 ± 0.3 mm vs. 1.9 ± 0.3 mm, respectively, p < 0.05). No significant coronary artery narrowing was present by magnetic resonance angiography. Overall, coronary vessel size increased 25.9 mm2 per millimeter increase in coronary wall thickness, whereas lumen area increased only slightly at 3.1 mm2 for every millimeter increase in wall thickness (difference in slopes, p < 0.0001). Adjusting for age and sex, participants with an Agatston score >0 were more likely to have wall thickness >2.0 mm (odds ratio: 2.0, 95% confidence interval: 1.01 to 3.84). Conclusions Coronary wall MRI detected positive arterial remodeling in asymptomatic men and women with subclinical atherosclerosis.