DTBP‐promoted Passerini‐type reaction of isocyanides with aldehydes: Synthesis of α‐acyloxycarboxamides

A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in...

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Published inJournal of the Chinese Chemical Society (Taipei) Vol. 69; no. 10; pp. 1794 - 1802
Main Authors Wang, Zhuo, Zhang, Yan, Wu, Zi‐Han, Zhao, Yu‐Long
Format Journal Article
LanguageEnglish
Published Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01.10.2022
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Abstract A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction. A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step.
AbstractList A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction.
Abstract A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction.
A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction. A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step.
Author Wu, Zi‐Han
Zhang, Yan
Zhao, Yu‐Long
Wang, Zhuo
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Snippet A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of...
Abstract A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide...
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SubjectTerms aldehyde
Aldehydes
Functional groups
isocyanides
Passerini reaction
α‐acyloxycarboxamides
Title DTBP‐promoted Passerini‐type reaction of isocyanides with aldehydes: Synthesis of α‐acyloxycarboxamides
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