DTBP‐promoted Passerini‐type reaction of isocyanides with aldehydes: Synthesis of α‐acyloxycarboxamides
A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in...
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Published in | Journal of the Chinese Chemical Society (Taipei) Vol. 69; no. 10; pp. 1794 - 1802 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
Wiley‐VCH Verlag GmbH & Co. KGaA
01.10.2022
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. The experimental results clearly confirmed the role of water and provided a better mechanistic understanding of this reaction.
A novel DTBP‐promoted Passerini‐type reaction of isocyanides with two molecular aldehydes has been developed. This reaction is applicable for a wide range of isocyanides and aldehydes and provides an efficient method for the synthesis of α‐acyloxycarboxamides with two identical functional groups in good to high yields in a single step. |
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Bibliography: | Funding information Natural Science Foundation of Jilin Province, Grant/Award Number: 20190201073JC; National Natural Science Foundation of China, Grant/Award Numbers: 21472017, 21871044 |
ISSN: | 0009-4536 2192-6549 |
DOI: | 10.1002/jccs.202200290 |